Disease models which are relevant to the clinical situation are essential for effective drug discovery.Ideally, the model should be mechanistically valid, have readouts which are similar to the clinic and predictive biomarkers.
VIVOPATH has significant expertise in the areas of metabolic, inflammatory, ophthalmic and hematologic diseases and with the following models in particular:
LPS-induced cytokine profile
Arthritis (KBN, CIA)
C. difficile infection
VIVOPATH can provide data on biomarkers and is very familiar with markers of metabolic disease, cytokine profiles and hematological markers.
VIVOPATH's staff have many years of experience in pharmacological validation of disease models and are able to set up models in house (regardless of clinical indication), assess their utility (testing of clinical standards) and use them efficiently to screen compounds.
Please contact us if you are in need of efficacy testing and we will be happy to discuss your program at no cost to you.